Popular Python PyPI projects

Compute distance between the two texts.

fasttext Python bindings

Microframework

Pytest support for asyncio

Command line utility to show dependency tree of packages.

Developer-friendly load testing framework

huey, a little task queue

Python compiler with full language support and CPython compatibility

Detect secrets from all sources using GitGuardian's brains

DeepSpeed library

Asteroids game simulation environment for ML and AI applications

Survival analysis in Python, including Kaplan Meier, Nelson Aalen and regression

TensorFlow is an open source machine learning framework for everyone.

Django Ninja - Fast Django REST framework

Django email backends and webhooks for Amazon SES, Brevo, MailerSend, Mailgun, Mailjet, Mandrill, Postal, Postmark, Resend, SendGrid, SparkPost and Unisender Go (EmailBackend, transactional email tracking and inbound email signals)

Scrobbler for trakt.tv that supports VLC, Plex, MPC-HC, and MPV

Auto-generate API documentation for Python projects.

SQLModel, SQL databases in Python, designed for simplicity, compatibility, and robustness.

Python GUIs for Humans! PySimpleGUI is the top-rated Python application development environment. Launched in 2018 and actively developed, maintained, and supported in 2025. Transforms tkinter, Qt, WxPython, and Remi into a simple, intuitive, and fun experience for both hobbyists and expert users.

Python Development Workflow for Humans.

Connexion - API first applications with OpenAPI/Swagger

Structured Logging for Python

A Python ASGI web framework with the same API as Flask

Litestar - A production-ready, highly performant, extensible ASGI API Framework

A Python framework for building reactive web-apps. Developed by Plotly.