wine-gecko-2.47.2 and wine-mono-6.0.0 have been bundled within this package, this should help if multiple wine prefixes are used reducing the install footprint.
wine64 was built with MoltenVK v1.1.2 support and will function on compatible systems just don't expect to be using DXVK.
wine64 was also built with VKD3D v1.2 support per request from @oscarbg, but this will lightly be useless outside of testing.
VKD3D was rebuilt using MoltenVK v1.1.2 all relevant dependencies were bumped accordingly.
jxrlib v1.1 a new dependency in upstream wine.
The embedded Runtime was build using the 10.13.SDK, I'll no longer be testing wine on systems below this version so the app bundle has the min version set to 10.13 but the actual wine binary wrapper was not rebuilt yet so best to install install via brew
wine & wine64 were compiled using a custom patched 10.14SDK that's the reason on Mojave wine title bars will match dark mode if activated.
Apple Silicon support?
From Wine-6.1 patches for running under Rosetta2 are included, like on Intel systems running macOS Catalina and later meaning only wine64 will function.
macOS Sierra and lower support?
I can't guarantee if the included runtime will function below macOS High Sierra, but wine & wine64 were built with a min target of 10.9 installing XQuartz may be required.
Don't report wine(64) issues to this repository!
File bug reports on Winehq's Bugzilla, you can file an issue here if wine(64) complains about a missing dylib otherwise report all issues on Winehq.